Gentamicin
Time to steady state: 1 day (longer in renal impairment).
Sampling time and target range
6-14 hours after dose: see plot in Gentamicin dosing guidelines (non-renal patients) on the Antimicrobial site – link only active if accessing from NHS network. Otherwise can be found via AthenA / Antimicrobial Guidelines and Information / Antimicrobial – specific guidance.
Comment

Dose depends on renal function.

It may be appropriate to check peak and trough levels in some patients (e.g. patients with high body weight). Aim for a peak (1 hour post-dose) >10mg/L and trough <1mg/L.

For renal patients or synergistic dosing and monitoring of gentamicin in endocarditis, refer to respective guideline on Antimicrobial site – link only active if accessing from NHS network. Otherwise can be found via AthenA / Antimicrobial Guidelines and Information / Antimicrobial – specific guidance.

 

Guideline reviewed: August 2021

Page updated: May 2022




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