Time to steady state: 1 day (longer in renal impairment).

See FAQ document – link only active if accessing from NHS network. Otherwise can be found via AthenA / Antimicrobial Guidelines and Information / Antimicrobial – specific guidance / Gentamicin, Vancomycin, Tobramycin, Amikacin FAQs.

Use patient specific dose in cystic fibrosis (CF).  If patient specific dose is not available, use gentamicin dosing calculator/guidelines for initial dosing and monitoring as pharmacokinetics of tobramycin are identical to gentamicin. Contact clinical/antimicrobial pharmacist for advice.