Infection

Limb cellulitis - inpatient treatment

Antibiotic Therapy (before prescribing, carefully read the Notes / Comments section below)

Flucloxacillin IV 2g 6 hourly


If true penicillin / beta-lactam allergy or suspected MRSA:

Vancomycin IV (dosing info here)

Duration
Total (IV and oral) up to 10 days
Notes / Comments
  • Cellulitis presents as an area of skin which has acutely become red, hot, tender, and swollen; it is not uncommon for blisters or bullae to develop.
  • The leg is the most common site and presentation is almost exclusively unilateral. Chronic venous eczema can mimic the appearance of cellulitis and be mislabelled as "bilateral cellulitis".
  • Minor breaks in the skin can act as portal of entry.
  • The most common causes of skin and soft tissue infections are S. aureus and S. pyogenes ("Group A Strep"). Flucloxacillin covers both organisms. Vancomycin covers both staphylococci (including MRSA) and streptococci.

 

 

Guideline reviewed July 2023
Page updated March 2024



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