| Infection |
|
Urosepsis
|
| Antibiotic Therapy (before prescribing, carefully read the Notes / Comments section below) |
|
Use the table below for the antimicrobial treatment overview of urosepsis.
|
| Duration |
| Total (IV and oral) 5-7 days |
| Notes / Comments |
- Gram negatives like E. coli, which is the most common cause of UTI, are always resistant to vancomycin, and usually resistant to amoxicillin (65% resistance in urinary isolates from secondary care and 70% resistance in bloodstream isolates). Gentamicin resistance rates of urinary gram negatives in both secondary care urinary and bloodstream isolates are <10%.
- Amoxicillin and vancomycin provide cover for enterococci only.
- Nitrofurantoin does not achieve therapeutic serum or tissue levels and is only used for treatment of uncomplicated lower UTI. It is not an appropriate agent for upper or bacteraemic UTI. Do not use as IV-to-oral switch in urosepsis.
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